Pre-2006 Research

Documents

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Detecting the Signal of the Menstrual Cycle in Fluorescence Spectroscopy of the Cervix

DENNIS D. COX,* SUNG K. CHANG, M. YUSOFF DAWOOD, GREGG STAERKEL, URS UTZINGER, REBECCA R. RICHARDS-KORTUM, and MICHELE FOLLEN

A Far-red Fluorescent Contrast Agent to Image Epidermal Growth Factor Receptor Expression

 Hsu E, Anslyn E, Dharmawardhane S, Alizadeh-Naderi R, Aaron J, Sokolov K, El-Naggar A, Gillenwater A, Richards-Kortum R; Photochemistry and Photobiology, 79(3): 272-279, 2004.

An Image Model and Segmentation Algorithm for Reflectance Confocal Images of in vivo Cervical Tissue

Kortum RR; IEEE Transactions on Image Processing, Volume 14, Issue 9, Page(s):1265 - 1276, Sept. 2005.

Autofluorescence Microscopy of Fresh Cervical-Tissue Sections Reveals Alterations in Tissue Biochemistry with Dysplasia

- Drezek R, Brookner C, Pavlova I, Boiko I, Malpica A, Lotan R, Follen M, and Richards-Kortum R; Photochemistry and Photobiology, 73(6):636-41, 2001.

Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue

Schwarz RA, Arifler D, Chang SK, Pavlova I, Hussain IA, Mack V, Knight B, Richards-Kortum R, Gillenwater AM; Optics Letters, 30(10): 1159-1161, May 2005.

Biomarker Modulation in a Nonhuman Rhesus Primate Model for Ovarian Cancer Chemoprevention

- Brewer M, Utzinger U, Satterfield W, Gershensen D, Bast R, Richards-Kortum R, and Follen M; Cancer Epidemiology, Biomakers & Prevention, 10(8):889-93, 2001.

Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers

Follen M, Meyskens FL Jr, Alvarez RD, Walker JL, Bell MC, Storthz KA, Sastry J, Roy K, Richards-Kortum R, Cornelison TL. Cancer. 98 (9 Suppl):2044-51, 2003 Nov 1.

Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer

Chang SK, Mirabal YN, Atkinson EN, Cox D, Malpica A, Follen M, Richards-Kortum R; J Biomed Opt., 10(2):024031, Mar-Apr 2005.

Confocal Microscopy for Detection of Precancerous Cervical Lesions

- Luck B, Carlson K, Collier T, Sung KB; IEEE Potentials, February 2004.

Confocal Microscopy for Real-Time Detection of Oral Cavity Neoplasia

Clark AL, Gillenwater A, Collier T, Alizadeh-Naderia R, El-Naggar A, Richards-Kortum R; Clinical Cancer Research, 9(13):4714-4721, 2003.

Confocal Microscopy of Amelanotic Tissue: Detection of Dysplasia in ex Vivo Cervical Tissue

Collier T, Lacy A, Malpica A, Follen M, and Richards-Kortum R; Academic Radiology, 9:504-512, 2001.

Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspension

- Zuluaga AF, Drezek R, Collier T, Lotan R, Follen M, and Richards-Kortum R; The Journal of Biomedical Optics, 7:398-403, 2002.

Detection and Diagnosis of Oral Neoplasia with an Optical Coherence Microscope

- Clark A. L., Gillenwater A., Alizadeh-Naderi R.,El-Naggar A. K., Richards-Kortum R.; Journal of Biomedical Optics 9(6):1271-1280, Nov/Dec 2004.

Determination of Epithelial Tissue Scattering Coefficient using Confocal Microscopy

Collier T, Arifler D, Malpica A, Follen M, Richards-Kortum R; IEEE Journal of Quantum Electronics, 9(2): 307-313, 2003.

Effect of Probe Pressure on Cervical Fluorescence Spectroscopy Measurements

- Nath A., Rivoire K., Chang S., Cox D., Atkinson E. N., Follen M., Richards-Kortum R.; Journal of Biomedical Optics, 9(3): 523-533, May/June 2004.

Effects of Biographical Variables on Cervical Fluorescence Emission Spectra

- Brookner C, Utzinger U, Follen M, Richards-Kortum R, and Atkinson EN; Journal of Biomedical Optics, 8:479-83, 2003.

Endoscopic Microscopy

- Sokolov K, Sung KB, Collier T, Clark A, Arifler D, Lacy A, Descour M, Richards-Kortum R; Disease Markers, 18(5,6): 269-292, 2002.

Fast and Noninvasive Fluorescence Imaging of Biologic Tissues in vivo Using a Flying-Spot Scanner

- Ramanujam N, Chen J, Gossage K, Richards-Kortum R, and Chance B; IEEE Transactions on Biomedical Engineering, 48(9):1034-,1041 2001.

Fiber confocal reflectance microscope (FCRM) for in-vivo imaging

- Liang C, Sung K, Richards-Kortum R, and Descour MR; Optics Express, 9(13):821-830, 2001.

Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo

- Sung KB, Liang C, Descour M, Follen M, Malpica A, Richards-Kortum R; 11(24):3171-3181, Optics Express, 2003.

Fiber optic probe for polarized reflectance spectroscopy in vivo:Design and performance

- Myakov A, Nieman L, Wicky L, Utzinger U, Richards-Kortum R, and Sokolov K; Journal of Biomedical Optics, 7(3):388-97, 2002.

Fiber optic probes for biomedical optical spectroscopy

- Utzinger U, Richards-Kortum R; Journal of Biomedical Optics, 8(1):121-147, 2003.

Fiber-Optic Confocal Reflectance Microscope with Miniature Objective for in vivo Imaging of Human Tissues

- Sung K, Liang C, Descour M, Collier T, Follen M, and Richards-Kortum R; IEEE Trans BME, 49:1168-1172, 2002.

Fluorescence spectroscopy as biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agents

- Brewer M, Utzinger U, Yang L, Atkinson EN, Satterfield W, Auersperg N, Richards-Kortum R, Follen M, and Bast R; Journal of Biomedical Optics, 7:20-26, 2002.

Fluorescence Spectroscopy for Cervical Pre-Cancer Detection: Is There Variance Across the Menstrual Cycle?

- Chang SK, Dawood MY, Staerkel G, Utzinger U, Richards-Kortum R, and Follen M; Journal of Biomedical Optics, in press, 2002.

Fluorescence Spectroscopy for in vivo Characterization of Ovarian Tissue

- Brewer M, Utzinger U, Silva E, Gershenson D, Bast RC, Follen M, and Richards-Kortum R; Lasers in Surgery and Medicine, 29:128-135, 2001.

Fluorescence Spectroscopy of Epithelial Tissue Throughout the Dysplasia-Carcinoma Sequence in an Animal Model: Spectroscopic Changes Precede Morphologic Changes

- Coghlan L, Utzinger U, Richards-Kortum R, Brookner C, Zuluaga A, Gimeniz-Conti I, Follen M; Lasers in Surgery and Medicine 29:1-10, 2001.

Formative and Summative Assessment of the IGERT Program in Optical Molecular Bio-Engineering at UT Austin

- Richards-Kortum R, Dailey M, Harris C; Journal of Engineering Education, 92(4):345-350, 2003.

High Resolution, Molecular-Specific Reflectance Imaging in Optically Dense Tissue Phantoms with Structured-Illumination

- Tkaczyk T, Rahmann M, Mack V, Sokolov K, Rogers J, Richards-Kortum R, Descour M; Optics Express, 12(16): 3745-3758, Aug 2004.

Imaging Quality Assessment of Multi-modal Miniature Microscope

- Lee J, Rogers JD, Descour MR, Hsu E, Aaron JS, Sokolov K, and Richards-Kortum R; Optics Express, Vol. 11:1436 - 1451, 2003.

In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens

Carlson K, Chidley M, Sung KB, Descour M, Gillenwater A, Follen M, Richards-Kortum R; Applied Optics, 44(10): 1792-1797, Apr 2005.

In vivo pathology: microendoscopy as a new endoscopic imaging modality

- MacAulay C., Lane P., Richards-Kortum R.; Gastrointestinal Endoscopy Clinics of North America. 14(3): 595-620, xi, 2004.

Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture

- Drezek R, Guillaud M, Collier T, Boiko I, Malpica A, Macaulay C, Follen M, Richards-Kortum R; Journal of Biomedical Optics, 8(1):7-16, 2003

Low temperature fluorescence imaging of freeze-trapped human cervical tissues

- Ramanujam N, Richards-Kortum R, Thomsen S, Mahadevan-Jansen A, Follen M, and Chance B; Optics Express. Vol. 8, No. 6, 335-343, 2001

Micro anatomical and Biochemical Origins of Normal and Precancerous Cervical Autofluorescence Using Laser Scanning Fluorescence Confocal Microscopy

Pavlova I, Sokolov K, Drezek R, Malpica A, Follen M, and Richards-Kortum R; Photochemistry and Photobiology, 77(5):550-5, 2003.

Multispectral Digital Colposcopy for in vivo Detection of Cervical Cancer

- Benavides JM, Chang S, Park SY, MacKinnon N, MacAulay C, Milbourne A, Malpica A, Follen M, and Richards-Kortum R; Optics Express, 11:1223-36, 2003

Near Real-Time in vivo fiber optic confocal microscopy: sub-cellular structure resolved

- Sung KB, Liang C, Descour M, Collier T, Follen M, and Richards-Kortum R; Journal of Microscopy, 207(2):137-145, 2001.

Near-Infrared Raman Spectroscopy for in vivo Detection of Cervical Precancers

- Utzinger U, Heintzelman DL, Mahadevan-Jansen A, Malpica A, Follen M, and Richards-Kortum R; Applied Spectroscopy, 55(8):955-959, 2001.

Optical Imaging of the Cervix

- Drezek R, Faupel M, Pitris C, Feld M, Brewer M, Richards-Kortum R, and Follen M; Cancer - Supplement, 98/9:2015-2027, 2003

Optical spectroscopy for detection of neoplasia

- Sokolov K, Follen M, and Richards-Kortum R; Current Opinion in Chemical Biology 6:651-658, 2002.

Optical Systems for in vivo Molecular Imaging of Cancer

- Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, KOrgel B, Descour M, Pasqualini R, Arap W, Lam A, Richards-Kortum R; Technology in Cancer Research and Treatment, 2(5):491-504, 2003.

Optimal Excitation Wavelengths for Discrimination of Cervical Neoplasia

- Chang SK, Follen M, Malpica A, Utzinger U, Staerkel G, Cox D, Atkinson EN, MacAulay C, and Richards-Kortum R; IEEE Trans BME, 49(10):1102-1111, 2002.

Optimal Visual Perception and Detection of Oral Cavity Neoplasia

- Utzinger U, Bueeler M, Oh S, Heintzelman D.L. Svistun E, Abd-El-Barr M, Gillenwater A, and Richards-Kortum R; IEEE Trans Biomed Eng, 50(3):396-9, 2003.

Patient Distress and Satisfaction with Optical Spectroscopy in Cervical Dysplasia Detection

- Basen-Engquist K, Shinn EH, Warneke C, de Moor C, Le T, Richards-Kortum R, and Follen M;Am J Obstet Gynecol. 2003 Oct;189(4):1136-42

Real-Time Vital Optical Imaging of Precancer Using Anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles

- Sokolov K., Follen M., Aaron J., Pavlova I., Malpica A., Lotan R., and Richards-Kortum R.; Cancer Research, 63:1999-2004, May 1, 2003.

Realistic three-dimensional epithelial tissue phantoms for biomedical optics

- Sokolov K, Galvan J, Myakov A, Lacy A, Lotan R, and Richards-Kortum R; The Journal of Biomedical Optics, 7:148-156, 2002.

Reflectance Spectroscopy for in vivo Characterization of Ovarian Tissue

- Utzinger U, Brewer M, Silva E, Gershensen D, Bast R, Follen Mitchell M, and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 28, 56-66, 2001.

Reflectance spectroscopy for in vivo detection of cervical precancer

- Mirabal YN, Chang SK, Atkinson EN, Malpica A, Follen M, and Richards-Kortum R; Journal of Biomedical Optics 7(4):587-594, 2002.

Relationship Between Collagen Autofluorescence of the Human Cervix and Menopausal Status

- Gill E, Malpica A, Alford R, Nath AR, Follen M, Richards-Kortum R, and Ramanujam N; Photochemistry and Photobiology, 77:653-658, 2003

The Effects of Repeated Spectroscopic Pressure Measurements on Fluorescence Intensity in the Cervix

- Rivoire K, Nath A, Cox D, Atkinson EN, Richards-Kortum R, Follen M; American Journal of Obstetrics and Gynecology, 191(5):1606-1617, 2004.

Towards the development of miniaturized imaging systems for detection of pre-cancer

- Descour MR, Karkkainen AHO, Rogers JD, Liang C, Kilic B, Madenci E, Rantala JT, Weinstein RS, Richards-Kortum RR, Anslyn EV, and Dupuis RD; IEEE Journal of Quantum Electronics 38:122-130, 2002.

Understanding the Contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implications

- Drezek R, Sokolov K, Utzinger U, Boiko I, Malpica A, Follen M, and Richards-Kortum R; Journal Biomedical Optics, 6(4): 385-396, 2001.

Variation of Fluorescence Spectroscopy during the Menstrual Cycle

- MacAulay C, Richards-Kortum R, Atkinson EN, Cox D, and Follen M; submitted to Optics Express, 2002.

Vision Enhancement System for Detection of Oral Cavity Neoplasia based on Autofluorescence

Svistun E, Alizadeh-Naderi R, El-Naggar A, Jacob R, Gillenwater A, Richards-Kortum R; Head & Neck, 26(3):205-15, 2004.